The Jim Henson Co. says Jane Henson, Co-creator of The Muppets, died on Tuesday at her Connecticut home. She was 78.

Jane Henson had been fighting cancer, reportedly for some time. Our thoughts are very much with her family and friends at this time.

But what a life Jane Henson had. She and Jim Henson met in a University of Maryland puppetry class in the mid-1950s, and they became creative and business partners in the development of the Muppets. They married five years later, going on to have five children together, before separating in 1986. The pair continued to work together on The Muppets, and remained heavily involved in The Jim Henson Company, even after the death of Jim in 1990.

She co-created the show Sam And Friends with Jim, the early forerunner to what would become The Muppets, and leaves behind a brilliant legacy of work.